Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice
نویسندگان
چکیده
منابع مشابه
Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phenotype of transgenic SOD1(G93A) mice. Here, we demonstrate that SMN protein is significantly reduc...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2014
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2013.09.030